Database : HANSEN Search on : TRANSFORMACAO LINFOCITICA [Subject descriptor] References found : 83 [refine] Displaying: 1 .. 20   in format [Detailed]

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Id: 17553 Author: Bottasso, O. A; Morini, J. C Title: Imunopatologia de la lepra Immunopathology of leprosy- Source: s.l; s.n; 1989. 3 p. . Abstract: Se comentan los estudios en convivientes íntimos de enfermos de Lepra, donde se observó una relación inversa entre grado y tiempo de exposición al Mycobacterium leprae (MI) y la magnitud de la respuesta inmune in vivo hacia el bacilo (reacción de Mitsuda); esta variable por otro lado, se halla influenciada por un importante grado de determinación genética. En un modelo murino experimental, la artritis por adyuvante, también se comprobó que el tratamiento con MI inducia una población de células esplénicas supresoras, con actividad regulatoria sobre la respuesta inmune celular. Se plantean además, las posible alteraciones inmunorregulatorias involucradas con la excesiva respuesta humoral que sirve de sustrato para la generación del episodio de eritema nudoso leproso (ENL) (AU). Descriptors: Imunidade Celular Formação de Anticorpos HANSENIASE/genet HANSENIASE/imunol ARTRITE EXPERIMENTAL/terap TRANSFORMACAO LINFOCITICA ANTIGENO DE MITSUDA/imunol MYCOBACTERIUM LEPRAEMURIUM/imunol Limits: HUMANO ANIMAL RATOS Location: BR191.1; 09332/s

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Id: 13942 Author: Maeda, Yumi; Gidoh, Masaichi; Ishii, Norihisa; Mukai, Chifumi; Makino, Masahiko Title: Assessment of cell mediated immunogenicity of Mycobacterium leprae-derived antigens ..- Source: s.l; s.n; 2003. 9 p. tab, graf. Abstract: The antigenicity of Mycobacterium leprae (M. leprae)-derived cell membrane fraction was examined using human dendritic cells (DCs). Immature DCs internalized and processed the cell membrane components, and expressed M. leprae-derived antigens (Ags) on their surface. The expression of MHC class II, CD86, and CD83 Ags on DCs and CD40 ligand (L)-associated IL-12 p70 production from DCs were up-regulated by the membrane Ags. Moreover these stimulated DCs induced significantly higher level of interferon-gamma (IFN-gamma) production by autologous CD4(+) and CD8(+) T cells than those pulsed with equivalent doses of live M. leprae or its cytosol fraction. Both subsets of T cells from tuberculoid leprosy patients also produced several fold more IFN-gamma than those from normal individuals. Furthermore, the intracellular perforin production in CD8(+) T cells was up-regulated in an Ag-dose dependent manner. These results suggest that M. leprae membrane Ags might be useful as the vaccinating agents against leprosy. (AU). Descriptors: ANTIGENOS DE BACTERIAS/imunol ANTIGENOS DE SUPERFÍCIE/imunol LINFOCITOS T CD4-POSITIVOS/imunol LIGANTE A CD40/fisiol LINFOCITOS T CD8-POSITIVOS/imunol CELULAS DENDRITICAS/imunol INTERFERON TIPO II/bios INTERLEUCINA-12/bios TRANSFORMACAO LINFOCITICA GLICOPROTEINAS DE MEMBRANA/bios MYCOBACTERIUM LEPRAE/imunol Limits: HUMANO SUPPORT, NON-U.S. GOV'T SUPPORT, U.S. GOV'T, P.H.S. Electronic Medium: http://www.ilsl.br Location: BR191.1; 09083/s

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Id: 13727 Author: Cheadle, Eleanor J; Selby, Peter J; Jackson, Andrew M Title: Mycobacterium bovis bacillus Calmette-Guérin-infected dendritic cells potently activate autologous T cells via a B7 and interleukin-12-dependent mechanism ..- Source: s.l; s.n; 2003. 10 p. graf. Abstract: Mycobacteria are potent adjuvants, can survive intracellularly and have been safely used for many years as vaccines against tuberculosis and leprosy. They are thus important potential vectors for recombinant vaccines. Many of their adjuvant properties are mediated following phagocytosis by dendritic cells (DC), which are in turn critical for priming naïve T cells. Although the maturation of DC in response to mycobacteria, such as Mycobacterium bovis bacillus Calmette-Guérin (BCG), is well described the subsequent responses of autologous T cells to mycobacterium-infected DC remains uncharacterized. In our experiments DC infected with BCG expressed more co-stimulatory molecules than tumour-necrosis factor-alpha (TNF-alpha) -treated DC and stimulated more potent mixed leucocyte reactions. When autologous T cells were co-cultured with BCG-exposed DC they became highly activated, as determined by display of CD25, CD54 and CD71 on both CD4+ and CD8+ cells. In contrast, the response of T cells to TNF-alpha-matured DC was significantly less. Cytokine production from T cells cultured with BCG-exposed DC was enhanced with elevated secretion of interleukin-2 (IL-2), IL-10 and interferon-gamma (IFN-gamma) and was produced by both CD4+ and CD8+ lymphocytes as determined by intracellular staining. In particular, IFN-gamma secretion was increased from 50 pg/ml to 25 000 pg/ml and IL-10 secretion increased from 20 pg/ml to 300 pg/ml in BCG-exposed DC co-cultures. Blocking antibodies to B7.1 and B7.2 or IL-12 significantly reduced the secretion of IFN-gamma and reductions were also seen in the expression of CD25 and CD71 by CD4+ cells. These data demonstrate that mycobacterially infected DC are particularly potent activators of autologous T cells compared to TNF-alpha-exposed DC and that the resultant T cells are functionally superior. (AU). Descriptors: ANTIGENOS CD/metab ANTIGENOS CD80/imunol ANTIGENOS DE DIFERENCIACAO DE LINFOCITOS B/metab LINFOCITOS T CD4-POSITIVOS/imunol LINFOCITOS T CD8-POSITIVOS/imunol CITOCINAS/bios CELULAS DENDRITICAS/imunol CELULAS DENDRITICAS/microbiol MOLECULA 1 DE ADESAO INTERCELULAR IMUNOFENOTIPAGEM INTERLEUCINA-12/imunol TRANSFORMACAO LINFOCITICA/imunol MYCOBACTERIUM BOVIS/imunol RECEPTORES DA INTERLEUCINA-2/metab LINFOCITOS T/imunol FATOR DE NECROSE TUMORAL/imunol REGULACAO PARA CIMA/imunol Limits: HUMANO SUPPORT, NON-U.S. GOV'T Electronic Medium: http://www.ilsl.br Location: BR191.1; 08996/s

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Id: 13666 Author: Bala, Lakshmi; Anand, Sukumar; Sinha, Sudhir Title: Enhancement of human T cell response to a peptide epitope of 38kDa antigen of Mycobacterium tuberculosis by liposomes ..- Source: s.l; s.n; 2002. 9 p. graf. Abstract: Diagnosis of tuberculosis a problem, specially in the regions harboring an abundance of both pathogenic and non-pathogenic mycobacteria. This study was undertaken to assess in such a situation the predictive value of proliferative T cell response to a peptide epitope ('38G') of the 38 kDa membrane protein of Mycobacterium tuberculosis. 3[H]-thymidine incorporation assays were done with peripheral blood mononuclear cells of tuberculoid leprosy and pulmonary tuberculosis patients. The donors were also classified as PPD responders (Stimulation Index, SI> 3) or non-responders (SI < or = 3) on the basis of their T cell response to the 'Purified Protein Derivative (PPD)' of M. tuberculosis. 38G peptide was used in either free or liposome-associated form prepared by the technique of 'Dehydration-rehydration Vesicles' (Kirby and Gregoriadis, 1984). While free peptide failed to induce a positive response in study subjects, its liposomal form was T cell stimulatory and distinguished, to certain extent, between PPD responders (corresponding SI > 3 in 54 per cent subjects) and non-responders (SI > 3 in 29 per cent subjects). However, it did not differentiate between leprosy and tuberculosis. The study supports use of liposomes as adjuvant vehicles for antigenic peptides designed to activate human T cells. (AU). Descriptors: ANTIGENOS DE BACTERIAS/admin ANTIGENOS DE BACTERIAS/quim ANTIGENOS DE BACTERIAS/genet HANSENIASE TUBERCULOIDE/diag HANSENIASE TUBERCULOIDE/imunol EPITOPOS/admin EPITOPOS/quim EPITOPOS/genet DIAGNOSTICO DIFERENCIAL MYCOBACTERIUM TUBERCULOSIS/quim MYCOBACTERIUM TUBERCULOSIS/genet MYCOBACTERIUM TUBERCULOSIS/imunol DADOS DE SEQUÊNCIA MOLECULAR SEQUÊNCIA DE AMINOACIDOS LINFOCITOS T/imunol TESTE TUBERCULINICO TUBERCULOSE PULMONAR/diag TUBERCULOSE PULMONAR/imunol TRANSFORMACAO LINFOCITICA - LIPOSSOMOS  PESO MOLECULAR Limits: ESTUDO COMPARATIVO HUMANO IN VITRO SUPPORT, NON-U.S. GOV'T Electronic Medium: http://www.ilsl.br Location: BR191.1; 09061/s

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Id: 13580 Author: Godal, Tore; Negassi, Kesete Title: Subclinical infection in leprosy ..- Source: s.l; s.n; September 15, 1973. 3 p. tab. Abstract: Lymphocyte transformation has been used to study the immune response to Mycobacterium leprae aomng contacts and non-contacts of leprosy patients. Of 26 subjects living a leprosy endemic area for less than two months none responded to M. leprae; 24% of subjects who had lived in an endemic area for more than a year gave a positive response to M. leprae; more than 50% of individuals with occupational contact of leprosy for more than a year responded; and about 50% of caontacts of tuberculoid and treated lepromatous patients responded to M. leprae, while only 22% (4/18) of contacts of leproamtous patients treated for less than six months responded. It seems that leprosy is more highly infectious than is indicated by the prevalence of the disease and that a subclinical infection commonly follows exposure to M. leprae. The relatively low response found in contacts of active lepromatous patients suggests that in these contacts "superexposure" to M. leprae can bring about a decrease in host resistance.(AU). Descriptors: TRANSFORMACAO LINFOCITICA ETIOPIA HABITACAO IMUNIDADE HANSENIASE/genet HANSENIASE/imunol HANSENIASE/microbiol MYCOBACTERIUM BOVIS/imunol MYCOBACTERIUM LEPRAE/imunol - FATORES DE TEMPO  DOENCAS OCUPACIONAIS Limits: HUMANO Electronic Medium: http://www.ilsl.br Location: BR191.1; 00624

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Id: 13560 Author: Purtilo, David T; Walsh, Gerald P; Storrs, Eleanor E; Banks, Isaac S Title: Impact of cool temperatures on transformation of human and armadilio lymphocytes ( Dasypus novemcinctus, Linn. ) as related to leprosy ..- Source: s.l; s.n; March 29, 1974. 3 p. tab, graf. Abstract: A CENTURY-LONG search for an unaltered animal in which to study leprosy in humans culminated in the finding that the nine-banded armadillo (Dasypus novemcinctus, Linn.) a primitive mammal native to the southern Western Hemisphere, develops disseminated lepromstous leprosy following inocuation with Mycobacterium leprae isolated from human tissue.(AU). Descriptors: TRANSFORMACAO LINFOCITICA/ef drogas MYCOBACTERIUM LEPRAE/imunol XENARTROS/imunol HANSENIASE/imunol LECTINAS MODELOS ANIMAIS DE DOENCAS ANTIGENOS DE BACTERIAS FRIO Limits: HUMANO ANIMAL MASCULINO FEMININO Electronic Medium: http://www.ilsl.br Location: BR191.1; 00494/s

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Id: 13501 Author: Haregewoin, Abebe; Godal, Tore; Mustafa, Abu Salim; Belehu, Ayele; Yemaneberhan, Tabebe Title: T-cell conditioned media reverse T-cell unresponsiveness in lepromatous leprosy ..- Source: s.l; s.n; May 26, 1983. 3 p. . Abstract: In some subjects the infective agent of leprosy, Mycobacterium leprae, causes disseminated (lepromatous) disease. Such subjects have a major role in the transmission of the disease and show deficient T-cell responses both in vivo and in vitro to M. leprae, but not to other antigens. Numerous studies have recently shown that T cells with functional capabilities after initial triggering with antigen can be maintained in a state of continuous proliferation in vitro when cultured in medium containing interleukin 2 (IL-2). Here we have studied the effect of IL-2 rich T-cell conditioned medium on lepromatous peripheral blood mononuclear cells. Our results show that although lepromatous T cells fail to produce IL-2 after exposure to M. leprae they can respond by proliferation to M. leprae in the presence of T-cell conditioned medium, suggesting that the unresponsiveness in lepromatous leprosy results from a deficiency in the production of IL-2 or related factors and not a lack of M. leprae-reactive T cells.(AU). Descriptors: MEIOS DE CULTURA TOLERÂNCIA IMUNOLOGICA INTERLEUCINA-2/imunol HANSENIASE/imunol TRANSFORMACAO LINFOCITICA LINFOCITOS T/imunol Limits: HUMANO SUPPORT, NON-U.S. GOV'T Electronic Medium: http://www.ilsl.br Location: BR191.1; 01401/s

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Id: 13500 Author: Mehra, Vijay; Mason, Llewellyn H; Fields, James P; Bloom, Barry R Title: Lepromin-induced suppressor cells in patients with leprosy ..- Source: s.l; s.n; oct. 1979. 5 p. tab, graf. Abstract: The possibility of an active mechanism of immunologic suppression in leprosy was explored by assessing the in vitro lymphocyte responses of 61 leprosy patients and 30 normal individuals to the mitogen Con A in the presence or absence of Dharmendra lepromin. Lepromin-induced suppression of Con A stimulation was found in 32 of 35 lepromatous patients and 15 of 15 borderline patients, but only 2 of 15 tuberculoid patients and 2 of 30 normal controls. Cell fractionation studies indicated at least two cell populations involved in the in vitro lepromin-induced suppressor activity, adherent cells and T gamma-cells.(AU). Descriptors: LINFOCITOS/clas TRANSFORMACAO LINFOCITICA HANSENIASE/imunol FORMACAO DE ROSETA LINFOCITOS T SUPRESSORES-EFETORES/imunol IMUNOGLOBULINA G/imunol ANTIGENO DE MITSUDA/imunol RECEPTORES FC/imunol CONCANAVALINA A/farmacol ADERÊNCIA CELULAR Limits: HUMANO SUPPORT, U.S. GOV'T, P.H.S. Electronic Medium: http://www.ilsl.br Location: BR191.1; 01400/s

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Id: 13486 Author: Roselle, G. A; Kauffman, C. A Title: Amphotericin B and 5-fluorocytosine: effects on cell-mediated immunity ..- Source: s.l; s.n; apr. 1980. 7 p. tab, graf. Abstract: Although single-dose amphotericin B therapy appears to be immunostimulatory in mice, no data are available regarding the effects of chronic anti-fungal drug therapy on the immune system. We studied the effects on the guinea-pig cellular immune system of 4 weeks of treatment with amphotericin B, 5-fluorocytosine, or the combination of both drugs. The in vitro lymphocyte response to phytohaemagglutinin and the specific antigen, picryl human serum albumin (picHSA), were not affected by anti-fungal drug treatment. At 1.5 weeks of therapy with amphotericin B, skin test reactivity to picHSA was significantly reduced but returned toward normal by the end of 3.5 weeks of drug therapy. Macrophage migration inhibitory factor production by guinea-pig peripheral blood lymphocytes was significantly reduced after 4 weeks of amphotericin B therapy. No immunostimulatory properties could be ascribed to amphotericin B. 5-fluorocytosine had no effect on cellular immunity.(AU). Descriptors: TESTES CUTÂNEOS FATORES INIBIDORES DA MIGRACAO DE MACROFAGOS/anal CONTAGEM DE LEUCOCITOS LINFOCITOS T/imunol IMUNIDADE CELULAR/ef drogas TRANSFORMACAO LINFOCITICA/ef drogas FLUCITOSINA/farmacol CITOSINA/analog ANFOTERICINA B/farmacol Limits: ANIMAL FEMININO COBAIAS SUPPORT, U.S. GOV'T, NON-P.H.S. Electronic Medium: http://www.ilsl.br Location: BR191.1; 01306/s

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Id: 13472 Author: Smelt, A. H; Liew, F. Y; Rees, R. J Title: Lymphocyte response of leprosy patients to human-derived and purified armadillo-derived Mycobacterium leprae, BCG and PPD ..- Source: s.l; s.n; nov. 1978. 6 p. graf. Abstract: The lymphocyte transformation test was applied to compare in vitro lymphocyte responses of tuberculoid (high resistant) and lepromatous (low resistant) leprosy patients to purified Mycobacterium leprae derived from experimentally infected armadillos and crude M. leprae derived from man, as well as to bacille Calmette-Guérin (BCG) and purified protein derivative (PPD). It was found that the purification procedure using enzymic digestion did not affect the immunogenicity of armadillo-derived M. leprae as compared with the crude human-derived preparation, although 2.5-5-fold higher doses of the purified organisms were required to elicitate equivalent lymphocyte responses. The result indicated the suitability of purified armadillo-derived M. leprae as the standard antigen for lymphocytes transformation tests in leprosy. The cross-reactivity studies show a close relationship between PPD and BCG, but not between M. leprae and PPD or BCG.(AU). Descriptors: TRANSFORMACAO LINFOCITICA HANSENIASE/imunol MYCOBACTERIUM BOVIS/imunol TUBERCULINA/imunol RELACAO DOSE-RESPOSTA IMUNOLOGICA TATUS/imunol VACINA BCG MYCOBACTERIUM LEPRAE/imunol Limits: HUMANO ANIMAL ADULTO MEIA-IDADE ADOLESCENTE Electronic Medium: http://www.ilsl.br Location: BR191.1; 01550/s

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Id: 13462 Author: Bach, Marie Anne; Chatenoud, Lucienne; Wallach, D; Phan Dinh Tuy, Françoise; Cottenot, F Title: Studies on T cell subsets and functions in leprosy ..- Source: s.l; s.n; jun. 1981. 10 p. tab, graf. Abstract: T cell subsets and T cell functions were explored in 31 leprosy patients with the following methods: determination of the percentages of the different T cell subpopulations defined by monoclonal antibodies directed at total T cells, helper T cells and suppressor/cytotoxic T cells; measurement of the in vitro proliferative responses to mitogens; study of the concanavalin A-induced suppressive activity, assessed on MLC; measurement of delayed-type hypersensitivity by skin testing. The confrontation between immunological lepromatous patients without type-2 reaction (erythema nodosum leprosum), (2) lepromatous patients without ENL (erythema nodosum leprosum), (2) lepromatous patients was recent ENL and (3) tuberculoid patients. Unexpectedly, groups 1 and 3, although differing strongly in their clinical status and their sensitivity to lepromin (absent in group 1 and strong in group 3), showed a similar immunological profile with a normal percentage of T cells and a normal distribution of T cells among the major T cell subset contrasting with a moderate decrease of proliferative responses to mitogens and impaired delayed-type hypersensitivity reactions. Concanavalin A-induced suppressive activity was type-2 reaction) strongly differed from both other groups, showing striking abnormalities other groups, showing striking abnormalities of the repartition of the T cell subsets, with increased percentages of helper T cells and decreased percentages of suppressor T cells, and elevated proliferative responses to mitogens. Concanavalin A-induced suppressive activity was reduced in most patients of this group. It is suggested that this imbalance between T cell subsets contributes to the occurrence of ENL reactions in lepromatous patients.(AU). Descriptors: ANTICORPOS MONOCLONAIS/imunol HANSENIASE/imunol TESTES INTRADERMICOS CONTAGEM DE LEUCOCITOS TRANSFORMACAO LINFOCITICA LINFOCITOS T/clas LINFOCITOS T/imunol LINFOCITOS T SUPRESSORES-EFETORES/imunol CONCANAVALINA A/farmacol Limits: HUMANO MASCULINO FEMININO ADULTO MEIA-IDADE IDOSO SUPPORT, NON-U.S. GOV'T ADOLESCENTE Electronic Medium: http://www.ilsl.br Location: BR191.1; 01450/s

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Id: 13433 Author: Brown, Arthur E; Vithayasai, Vicharn; Scollard, David M; Nelson, Kenrad E; Moses, Vijai; Schauf, Victoria; Makonkawkeyoon, Sanit Title: Lymphocyte transformation in lepromatous leprosy: a study of the influence of disease activity and symptom duration ..- Source: s.l; s.n; mar. 1986. 7 p. tab, graf. Abstract: The lymphocyte hyporesponsiveness to M. leprae of patients with active lepromatous leprosy has been well described. This immune defect is less well understood in terms of its time of origin, possible reversibility and specificity. To further examine the persistence and specificity of this abnormality, lymphocyte transformation tests of 93 leprosy patients to lepromin, BCG and PHA were studied. Among lepromatous patients, a decreased response to M. leprae was seen, whether the disease was active or inactive. Decreased responses to BCG were found in lepromatous patients with active disease, but not in those with inactive disease. The duration of patient symptoms was not associated with differences in LTT responses among the active lepromatous patients.(AU). Descriptors: FITOHEMAGLUTININAS/farmacol TRANSFORMACAO LINFOCITICA HANSENIASE/imunol HANSENIASE/terap ANTIGENO DE MITSUDA VACINA BCG/farmacol Limits: HUMANO MASCULINO ADULTO MEIA-IDADE SUPPORT, NON-U.S. GOV'T SUPPORT, U.S. GOV'T, P.H.S. ADOLESCENTE Electronic Medium: http://www.ilsl.br Location: BR191.1; 01763/s

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Id: 13416 Author: Bjune, G Title: In vitro lymphocyte stimulation in leprosy; simultaneous stimulation with Mycobacterium leprae antigens and phytohaemagglutinin ..- Source: s.l; s.n; jun. 1979. 9 p. tab, graf. Abstract: Peripheral blood lymphocytes from 105 subjects with different forms of leprosy and healthy contacts of leprosy patients weere stimulated in vitro different preparations of mycobacterial antugens alone or in combination with a suboptimal dose of phytohaemagglutinin (PHA). In nearly all individuals sonicated leprosy bacilli and PHA together gave a lower 3H-thymidine incorporation than didi the same dose of PHA alone. There was no difference in the degree of inhibition seen in the different patient groups or the healthy contacts. High doses of whole, washed Mycobacterium leprae, combined with PHA led to an increased thymidine incorporation in borderline tuberculoid leprosy patients who had experienced a reversal reaction, and in healthy contacts with less than 6 months exposure did not show an augmentation of the PHA-induced thymidine incorporation. The inhibition exerted by sonicated M. leprae was dose-dependent, seen even with very low doses of antigen, and was not due to direct Cytotoxicity, M. bovis, strain BCG, was weakly suppressive effect. There was no correlation between the suppressive effective of M. leprae antigens and the other mtcobacteria neither was there any correlation with the responses to the mycobacterial antigens alone. Many lepromatous leprosy patients showed significant suppression of background incorporation with addition of M. leprae antigens. This paper discusses wheter the apparent `non-responsiveness` in lepromatous leprosy could be due to active suppressor mechanisms operative in vitro.(AU). Descriptors: ANTIGENOS DE BACTERIAS/imunol ANTIGENOS DE SUPERFÍCIE/imunol HANSENIASE/imunol HANSENIASE/metab TRANSFORMACAO LINFOCITICA TIMIDINA/metab FITOHEMAGLUTININAS/farmacol MYCOBACTERIUM LEPRAE/imunol RELACAO DOSE-RESPOSTA IMUNOLOGICA LINFOCITOS/metab Limits: HUMANO Electronic Medium: http://www.ilsl.br Location: BR191.1; 00020/s

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Id: 13415 Author: Nelson, D. S; Penrose, J. M; Waters, M. F; Pearson, J. M; Nelson, M Title: Depressive effect of serum from patients with leprosy on mixed lymphocyte reactions ..- Source: s.l; s.n; dec. 1975. 8 p. tab. Abstract: Mixed leucocyte cultures, from two normal donors, were set up in media containing human serum from one of the following sources: (a) a pool of normal group AB donors; (b) Chinese, Malay or Indian patients with untreated leprosy; (c) the same patients after effective anti-leprosy treatment; (d) control Chinese, Malay or Indian subjects. Transformation was estimated by measuring the incorporation of tritiated thymidine in the last 24 hr of a 7-day culture period. Transformation was impaired in sera from treated lepromatous patients, but was less impaired or not impaired at all in sera from treated lepromatous patients. The loss of depressive activity after treatment was more marked in Chinese and Indian than in Malay patients. Transformation was also impaired, though to a lesser extent, in sera from patients with untreated tuberculoid leprosy; it was still impaired in sera from treated tuberculoid patients. There was no evidence of specificity in impairment of mixed lymphocyte reactivity and lymphocytotoxic antibodies appeared to play no role. The incidences of hepatitis B antigen and antibody and of anti-nuclear factor were not notably high.(AU). Descriptors: ANTICORPOS ANTINUCLEARES ESPECIFICIDADE DE ANTICORPOS DAPSONA/uso terap GRUPOS ETNICOS ANTIGENOS DA HEPATITE B HANSENIASE/quimioter HANSENIASE/imunol TESTE DE CULTURA MISTA DE LINFOCITOS TRANSFORMACAO LINFOCITICA Limits: HUMANO MASCULINO FEMININO CRIANÇA ADULTO MEIA-IDADE IDOSO ADOLESCENTE Electronic Medium: http://www.ilsl.br Location: BR191.1; 00021/s

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Id: 13329 Author: Salgame, Padmini R; Mahadevan, P. R; Antia, Noshir H Title: Mechanism of immunosuppression in leprosy: presence of suppressor factor(s) from macrophages of lepromatous patients ..- Source: s.l; s.n; jun. 1983. 8 p. tab, graf. Abstract: Human peripheral blood mononuclear cell proliferation induced by Mycobacterium leprae could...(AU). Descriptors: HANSENIASE/imunol LINFOCINAS/anal LINFOCINAS/farmacol FATORES INIBIDORES DA MIGRACAO DE MACROFAGOS/antag FATORES INIBIDORES DA MIGRACAO DE MACROFAGOS/anal FATORES INIBIDORES DA MIGRACAO DE MACROFAGOS/farmacol MYCOBACTERIUM LEPRAE/imunol LINFOCITOS T/imunol LINFOCITOS T SUPRESSORES-EFETORES/imunol - CONCANAVALINA A/farmacol  TOLERÂNCIA IMUNOLOGICA  TRANSFORMACAO LINFOCITICA  MACROFAGOS/imunol  MYCOBACTERIUM/imunol  FATORES SUPRESSORES IMUNOLOGICOS  FATORES DE TEMPO Electronic Medium: http://www.ilsl.br Location: BR191.1; 01218/s

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Id: 13327 Author: Convit, Jacinto; Aranzazu, N; Pinardi, M; Ulrich, M Title: Immunological changes observed in indeterminate and lepromatous leprosy patients and Mitsuda-negative contacts after the inoculation of a mixture of Mycobacterium leprae and BCG ..- Source: s.l; s.n; may 1979. 7 p. tab, graf. Abstract: This investigation was carried out to study the possibility of eliciting favourable immunological changes in small groups of Mitsuda-negative patients...(AU). Descriptors: ANTIGENOS DE BACTERIAS TATUS VACINA BCG ANTIGENO DE MITSUDA/imunol HANSENIASE/imunol HANSENIASE/terap MYCOBACTERIUM LEPRAE/imunol - TRANSFORMACAO LINFOCITICA  FATORES DE TEMPO  VACINACAO Limits: CRIANÇA ADOLESCENTE Electronic Medium: http://www.ilsl.br Location: BR191.1; 01020/s

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Id: 13324 Author: Rea, T. H; Quismorio, F. P; Harding, B; Nies, K. M; Di Saia, P. J; Levan NE;; Friou GJ Title: Immunologic responses in patients with lepromatous leprosy ..- Source: s.l; s.n; jun. 1976. 10 p. tab, graf. Abstract: Immunologic responses were measured in 46 patients with lepromatous leprosy. These patients were not distinguishable from controls on the basis of responses to soluble intradermal antigens, sensitization to contactants, peripheral blood T- and B-cell percentages, in vitro lymphocyte responses to a mitogen, or the prevalence of autoantibodies. Generalized immunologic abnormalities in patients with lepromatous leprosy are neither predisposing causes nor necessary accompaniments of lepromatous leprosy, but are probably remote sequellae of the illness. By implication, the generalized immunologic abnormalities reported in other diseases are likely to be remote sequellae of the particular illness.(AU). Descriptors: DERMATITE ATOPICA/ind quim DERMATITE DE CONTATO/etiol LECTINAS/farmacol ANTIGENO DE MITSUDA/farmacol HANSENIASE/clas HANSENIASE/genet HANSENIASE/imunol PELE/imunol LINFOCITOS T/imunol - DINITROCLOROBENZENO  DINITROFLUOROBENZENO  ANTIGENOS  AUTO-ANTICORPOS  LINFOCITOS B/imunol  CONTAGEM DE LEUCOCITOS  TRANSFORMACAO LINFOCITICA Limits: HUMANO MASCULINO FEMININO ADULTO MEIA-IDADE IDOSO Electronic Medium: http://www.ilsl.br Location: BR191.1; 01265/s

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Id: 13315 Author: Haregewoin, Abebe; Godal, Tore; Mustafa, Abu Salim; Belehu, Ayele; Yemaneberhan, Tabebe Title: T-cell conditioned media reverse T-cell unresponsiveness in lepromatous leprosy ..- Source: s.l; s.n; may 1983. 3 p. ilus, tab. Abstract: In some subjects the infective agent of leprosy, Mycobacterium leprae, causes disseminated (lepromatous) disease. Such subjects have a major role in the transmission of the disease and show deficient T-cell responses both in vivo and in vitro to M. leprae, but not to other antigens. Numerous studies have recently shown that T cells with functional capabilities after initial triggering with antigen can be maintained in a state of continuous proliferation in vitro when cultured in medium containing interleukin 2 (IL-2). Here we have studied the effect of IL-2 rich T-cell conditioned medium on lepromatous peripheral blood mononuclear cells. Our results show that although lepromatous T cells fail to produce IL-2 after exposure to M. leprae they can respond by proliferation to M. leprae in the presence of T-cell conditioned medium, suggesting that the unresponsiveness in lepromatous leprosy results from a deficiency in the production of IL-2 or related factors and not a lack of M. leprae-reactive T cells.(AU). Descriptors: MEIOS DE CULTURA TOLERÂNCIA IMUNOLOGICA INTERLEUCINA-2/imunol HANSENIASE/imunol LINFOCITOS T/imunol - TRANSFORMACAO LINFOCITICA Limits: HUMANO SUPPORT, NON-U.S. GOV'T Electronic Medium: http://www.ilsl.br Location: BR191.1; 01176/s

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Id: 13283 Author: Bahr, G. M; Rook, G. A. W; Stanford, J. L Title: Prostaglandin-dependent regulation of the in vitro paroliferative response to mycobacterial antigens of peripheral blood lymphocytes from normal donors and from patients with tuberculosis or leprosy ..- Source: s.l; s.n; sep. 1981. 8 p. tab, graf. Abstract: The response to soluble mycobacterial antigens of peripheral blood mononuclear cells, from most normal donors, tuberculosis patients or cases of tuberculoid leprosy (TT/BT) was enhanced by the addition of indomethacin. In contrast, indomethacin caused no enhancement of the response of cells from lepromatous leprosy (BL/LL) cases. Moreover the addition of 10-5M prostaglandin E2 (PGE2) failed to inhibit the proliferative responses of cells from the BL/LL patients, although it markedly inhibited the responses of peripheral blood mononuclear cells from the other groups. The addition of PGE2 or indomethacin to cells which had been precultured for 48 hours had no significant effect on the proliferative responses of cells from any of the groups of donors. These results suggest that a normal, prostaglandin-dependent, indomethacin-sensitive regulatory mechanism is absent from the peripheral blood mononuclear cells of BL/LL patients.(AU). Descriptors: ANTIGENOS DE BACTERIAS/imunol ANTIGENOS DE FUNGOS/imunol CANDIDA ALBICANS/imunol DIVISAO CELULAR/ef drogas DINOPROSTONA RELACAO DOSE-RESPOSTA A DROGA INDOMETACINA/farmacol HANSENIASE/imunol TRANSFORMACAO LINFOCITICA/ef drogas MYCOBACTERIUM/imunol - LINFOCITOS/imunol Limits: HUMANO SUPPORT, NON-U.S. GOV'T Electronic Medium: http://www.ilsl.br Location: BR191.1; 00540/s

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Id: 13282 Author: Hirschberg, H Title: The role of macrophages in the lymphoproliferative response to mycobacterium leprae in vitro ..- Source: s.l; s.n; oct. 1978. 6 p. tab. Abstract: Peripheral blood lymphocytes from patients suffering from lepromatous leprosy do not normally react in vitro stimulation by Mycobacterium leprae antigens. In contrast, we found that T cells from non-responding patients in combination with macrophages from responding patients or healthy contacts did respond well to M. leprae. Conversely, T cells from responding patients or healthy contacts in combinations with macrophages from non-responding patients failed to respond. I seems, therefore, that the lack of response normally observed in in vitro tests using cells from lepromatous leprosy patients is due to a failure of their macrophages to present M. leprae antigens is an immunogenic form.(AU). Descriptors: ANTIGENOS DE BACTERIAS/imunol HANSENIASE/imunol TRANSFORMACAO LINFOCITICA COOPERACAO LINFOCITICA MACROFAGOS/imunol MYCOBACTERIUM LEPRAE/imunol LINFOCITOS T/imunol Limits: HUMANO Electronic Medium: http://www.ilsl.br Location: BR191.1; 00541

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